|
KMID : 0191120000150060627
|
|
Journal of Korean Medical Science
2000 Volume.15 No. 6 p.627 ~ p.630
|
|
|
Effectiveness of Propofol Pretreatment on the Extent of Deranged Cerebral Mitochondrial Oxidative Enzyme System after Incomplete Forebrain Ischemia/Reperfusion in Rats
|
|
Lee Y
Chung C/Oh YS
|
|
|
Abstract
|
|
|
It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury.
The aim of this study is to evaluate the effect of propofol pretreatment on incomplete forebrain
ischemia-reperfusion injury in rats. Thirty Sprague-Dawley rats were anesthetized with isoflurane in
oxygen and randomly allocated into propofol group (n=13) and saline group (n=17). In propofol group,
propofol was pretreated in a step-down scheme before inducing forebrain ischemia by occlusion of both
common carotid arteries and arterial hypotension. After ischemia (20 min) and reperfusion (30 min), rats
were decapitated. Brain was sliced to obtain coronal slices of 4-12 mm from frontal pole, which were
reacted with 2% 2,3,5-triphenyl-2H-tetrazolium chloride (TTC) for 10 min to differentiate the damaged
tissues from normal tissues. Median (interquartile range) values of the average percent infarct area were
0.0 (8.6)% and 20.1 (41.2)% in propofol and saline groups, respectively. There was significant difference
between the groups. In conclusion, propofol may have a protective effect on incomplete forebrain
ischemia-reperfusion injury.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|